Rachael Nimmo
Dr. Rachael Nimmo completed her DPhil at the University of Oxford in 2005 followed by postdoctoral work at Oxford and Yale. In 2015 she established her independent research group at the UCL Cancer Institute to study the genetic and molecular mechanisms of leukaemia with funding from the Kay Kendall Leukaemia Fund, Bloodwise, Children with Cancer, and Cancer Research UK.
In 2018, seeking to have greater impact on improving outcomes for patients, she moved to Oxford Biomedica (OXB) to lead the Cell Technology Group. Here she began working on developing technology to enable the generation of CAR T cells in vivo, directly within the patient, motivated by the observation that despite the truly curative potential of CAR T cells, only a small fraction of eligible patients will receive this type of treatment due to the cost and complexity of these therapies. She reasoned that if a single infusion of a lentiviral vector could specifically generate sufficient CAR T cells in vivo, this would democratize access to these transformative therapies. As a result, her team have successfully developed an efficient, retargeted 4th generation lentiviral vector platform for in vivo CAR T cell therapy with the aim of delivering these treatments to more patients.